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Anabolic androgenic steroids (AAS) are a class of natural and synthetic steroid hormones that promote cell growth and division, resulting in growth of several types of tissues, especially muscle and bone.

Anabolic steroids were first discovered in the early 1930s and have since been used for numerous medical purposes including stimulation of bone growth, appetite, puberty, and muscle growth. The most wide spread use of anabolic steroids is their use for chronic wasting conditions including cancer and AIDS.

Anabolic steroids can produce numerous physiological effects including increased protein synthesis, muscle mass, strength, appetite and bone growth. Anabolic steroids have also been associated with numerous side effects when administered in excessive doses and these include elevated cholesterol (increase in LDL, decreased HDL levels), acne, elevated blood pressure, hepatotoxicity, and alterations in left ventricle morphology.

Today anabolic steroids are controversial because of their widespread use in numerous sports and their purported side effects.

It's widely understood that supraphysiological doses of testosterone in non-hypogonadalmen promotes nitrogen density and increases fat free mass (muscle mass) while at the same time decreasing fat, particularly abdominal fat. The increase in muscle mass is mostly skeletal muscle increases and is likely caused by an increase in the synthesis of muscle proteins or possibly a decline in the breakdown in muscle proteins.

The mechanisms of action differ depending on the specific anabolic steroid. Different types of anabolic steroids bind to the androgen receptor to different degrees depending on their chemical makeup.

There are three common routes for the administration of anabolic steroids: oral (for steroids in pill form), injectable, and transdermal. Oral administration, while perhaps the most convenient, suffers from the fact that oral steroids need to be chemically modified, and their metabolism into the active form can place strain on the liver. Injectable steroids are typically administered intramuscularly, to avoid sharp blood level changes. Finally, transdermal administration via cremes or transdermal patches has been gaining popularity in recent years.

Most anabolic steroids work in two simultaneous ways. First, they work by binding the androgen receptor and increasing protein synthesis. Second, they also reduce recovery time by blocking the effects of the stress hormone, cortisol, on muscle tissue. As a result, catabolism of the body's muscle mass is greatly reduced.

Men may experience shrinking of the testicles; reduced sperm count, infertility, baldness, breast development, and increased risk of prostate cancer. Women may experience growth of facial hair, male-pattern baldness, changes or cessation in menstrual cycle, and deepening of the voice.

Emotional problems associated with steroid use include dramatic mood swings (including manic symptoms that can lead to violence), depression, paranoid jealousy, extreme irritability, delusions, and impaired judgment.

:: RECENT NEWS ::

24/01/07 NFL, NFLPA improve steroids program
The National Football League and NFL Players Association have reached agreement on a series of improvements to their policy and program on anabolic steroids and related substances, it was announced read more... 05/01/07 To Inhale or Not to Inhale Steroids.
We've all seen the ads from Partnership for a Drug Free America that warn us and our children not to take steroids - a piece of sound medical and moral advice. But this public campaign could be harming our children's health. read more...

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