Product	Description	Quantity	Form	Manufacturer	Price	Order
Skinoren	30 gr 20%	1	Cream	Schering	$ 20.00

Skinoren

Note: If this brand is out of stock, another brand will be send to you. Active ingredient and concentration will be the same.

The antimicrobial property of azelaic acid and a direct influence on follicular hyperkeratosis are assumed to be the basis for the therapeutic efficacy of Skinoren Acne Cream in acne. Azelaic acid exerts an antibacterial effect on Propionibacterium acnes and causes a significant reduction of the colonisation density of Propionibacterium acnes. A significant reduction of the fraction of free fatty acids in the skin surface lipids also occurs.

In animal experiments azelaic acid inhibits the proliferation of cultivated keratinocytes (suppression of DNA synthesis) and accelerates the comedolysis of tetradecane-induced comedones. After treatment with Skinoren Acne Cream ultrastructural changes in particular of the keratohyaline granules and of filaggrin, an important factor in keratinisation occurred. These findings suggest that, under clinical conditions, Skinoren Acne Cream affects the keratinocytes and the pattern of keratinisation.

The amount of azelaic acid recovered in the viable epidermis and the corium increased with the time of exposure and was approximately 9,5% of the applied dose after 24 hours. Following topical application of 1 g azelaic acid (5 g Skinoren Acne Cream) to human volunteers 2,2% (+ 0,7%) of the dose was excreted as unchanged substance in the urine within 72 hours.

INDICATIONS
Topical treatment of mild to moderate acne vulgaris.

SIDE EFFECTS AND SPECIAL PRECAUTIONS
Skinoren Acne Cream lacks the potential for bleaching hair and clothes. Local skin irritation (eg reddening or scaling, itching and burning) may occur, usually at the start of treatment, but it usually regresses in the course of treatment. Photosensitivity reactions have been reported. Care must be taken that Skinoren Acne Cream does not come into contact with the eyes. If it does, the eyes should immediately be thoroughly rinsed with copious amounts of water.